Protein toxicity with proteinuria can result in those with preexisting kidney disease, or those who have lost kidney function due to age.
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Protein toxicity occurs when the body is unable to get rid of the potentially toxic wastes that are generated as a result of protein metabolism.
Protein toxicity occurs when an individual with impaired kidney function consumes protein rich diet. Specifically proteins from animal sources that are rapidly absorbed into the blood stream and are rapidly metabolized causing the release of high concentration of toxic nitrogenous waste materials. (Citation?)
Unexplained vomiting and a loss of appetite are indicators of protein toxicity. If those two symptoms are accompanied by an ammonia quality on the breath the on-set of kidney failure is a likely culprit. People with kidney disease, who are not on dialysis, are advised to avoid consumption of protein if possible, as consuming too much accelerates the condition and can lead to death. Most of the problems stem from the accumulation of unfiltered toxins and wastes from protein metabolism.
Kidney function naturally declines with age due to the gradual loss of nephrons (filters) in the kidney. Therefore, a 90-year old cannot safely consume the same amount of protein as a 20-year old.
Common causes of kidney disease include diabetes, heart disease, long term untreated high blood pressure, as well as abuse of analgesics like ibuprofen, aspirin, paracetamol and acetaminophen. Kidney disease like the Polycyctic Disease can be genetic in nature and progress as the patient ages.
A confirmation of Kidney failure is obtained by performing a blood test which measures the concentration of Creatinine and Urea.